9,10-Bis[(4-(2-hydroxyethyl)piperazine-1-yl)prop-2-yne-1-yl]anthracene: Synthesis and G-quadruplex Selectivity

9,10-Bis[(4-(2-hydroxyethyl)piperazine-1-yl)prop-2-yne-1-yl]anthracene: Synthesis and G-quadruplex Selectivity

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G-quadruplex DNA is the target of several natural and synthetic small molecules with antiproliferative and antiviral activity.We here report the synthesis through Sonogashira reaction folk rivet sweat and A3 coupling of a disubstituted anthracene derivative, 9,10-bis[(4-(2-hydroxyethyl)piperazine-1-yl)prop-2-yne-1-yl]anthracene.The binding of this compound to G-quadruplex and double stranded DNA sequences was evaluated using electrospray ionization mass spectrometry (ESI-MS), demonstrating selectivity for the first structure.

The interaction pattern of lightemupsequences.com the ligand with G-quadruplex was investigated by molecular docking and stacking was found to be the preferred binding mode.